Until recently, IBD surveillance has relied upon colonoscopy with multiple (at least 33) random biopsies of the bowel lining to detect dysplasia, but now international guidelines recommended a technique called chromoendoscopy. endobj Chromoendoscopy increased the overall detection rate for adenomas (0.95 vs 0.66 per patient), flat adenomas (0.56 vs 0.28 per patient) and serrated lesions (1.19 vs 0.49 per patient) (p < 0.001). Study record managers: refer to the Data Element Definitions if submitting registration or results information. In 23% of cases, flat lesions or flat lesions with depressions were diagnosed. We therefore aim to perform a randomised control trial, comparing 0.03% indigo-carmine dye versus 0.2% in detecting dysplasia in patients undergoing surveillance colonoscopy in IBD. Methylene blue, which stains the normal absorptive epithelium of the small intestine and colon, has been used to Please enable it to take advantage of the complete set of features! Am J Gastroenterol. %���� For general information, Learn About Clinical Studies. Used in concentrations ranging from 0.1 to 0.4%, indigo carmine is a surface contrast material, i.e. There is no standard international concentration of the dye spray used during chromoendoscopy. Singh R, Chiam KH, Leiria F, Pu LZCT, Choi KC, Militz M. Transl Gastroenterol Hepatol. endobj Get the latest public health information from CDC: https://www.coronavirus.gov. You must declare any conflicts of interest related to your comments and responses. Please confirm that you would like to log out of Medscape. Experimental: Patients with extensive colitis, 18 Years to 100 Years (Adult, Older Adult), Contact: Venkataraman Subramanian, MBBS, MRCP, MD, Number of patients with at least low grade dysplasia detected by targeted biopsy using 0.2% indigo-carmine compared with 0.03% indigo-carmine. Epub 2013 May 3. This website also contains material copyrighted by 3rd parties. In a prospective, randomised two-centre trial, PCC (with 0.4% indigo carmine spraying during continuous extubation) was compared with standard colonoscopy (control group) in consecutive patients attending for routine colonoscopy. Colonoscopy Including Indigo Carmine Dye Spray. Many nurses and physicians are most familiar with india ink and Spot. 4 0 obj 2 0 obj Pancolonic chromoendoscopy markedly enhances adenoma detection rates in an average-risk population and is practicable enough for routine application. METHODS: In a prospective, randomised two-centre trial, PCC (with 0.4% indigo carmine spraying during continuous extubation) was compared with standard colonoscopy (control group) in consecutive patients attending for routine colonoscopy. U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The histopathology of the lesions detected was confirmed by evaluating the endoscopic resection or biopsy specimens. Chromoendoscopy: role in modern endoscopic imaging. Poor extension of the surrounding colonic wall, Coarse surface findings (surface roughness), Suggestive colonoscopic findings for polypoid-type T1b (≥1000 μm) carcinomas: (a) expansion appearance, (b) tumor stiffness, surface unevenness, (c, d) converging folds toward the tumor and stiffness of the colonic lumen, Conventional colonoscopic findings suggestive of F&D type T1b (≥1000 μm) carcinoma lesions, Poor extension of the surrounding colonic wall, Similarly, useful conventional colonoscopic findings suggestive of F&D-type T1b carcinomas are shown in Table, Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window), Click to share on Google+ (Opens in new window), on Colonoscopy Including Indigo Carmine Dye Spray, Submucosal Dissection for T1 Colorectal Cancer, Ultrasound Sonography Including High-Frequency Ultrasound Probes, Endoscopy: Image-Enhanced Endoscopy Focused on JNET Classification—Narrow-Band Imaging (NBI), for Colorectal EMR/ESD from Japanese Guidelines (JGES, JSGE, JSCCR), Endoscopic Management of Colorectal T1(SM) Carcinoma. Followed a month post colonoscopy to evaluate the occurrence of undesirable events.
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